Product Care: Guidelines for SLU PP 332

Store in a cool, dry place away from light.  For longer term storage, freezing at -20°C is recommended to maintain integrity.

Introduction to Product Care

Proper handling and storage of SLU-PP-332 are essential to preserve its potency and ensure reliable results in research applications. As a powerful exercise mimetic, SLU-PP-332 is widely studied for its ability to enhance fatty acid oxidation, stimulate mitochondrial biogenesis, and improve whole body metabolism—particularly in models involving obese mice and skeletal muscle. Maintaining the stability of this compound is critical for experiments investigating metabolic diseases, energy metabolism, and the physiological effects of increased exercise capacity.

To support accurate and reproducible findings, SLU-PP-332 should always be stored in a cool, dry environment, shielded from light, and, for extended periods, kept at -20°C. Careful handling minimizes the risk of contamination or degradation, which is especially important when studying its impact on skeletal muscle function, body weight regulation, and mitochondrial activity in animal models. Additionally, proper disposal protocols must be followed to ensure laboratory safety and compliance with research standards.

By adhering to these guidelines, researchers can confidently explore the effects of SLU-PP-332 on fatty acid oxidation, energy metabolism, and mitochondrial biogenesis, advancing our understanding of metabolic diseases and the potential of exercise mimetics in experimental therapeutics.

SLU-PP-332 Product Note: Obese Mice

All products such are shipped in lyophilized or powder form and must be reconstituted to a liquid for research and testing. SLU-PP-332 is a synthetic, small-molecule compound developed for research purposes by researchers at Saint Louis University (SLU), also known as louis university. SLU-PP-332 is commercially available for research purposes. We are unable to provide any dosing instructions. All peptides are for research use only. We’re an expert biotechnology company that provides high quality peptides and products for purchase to advance scientific research in this field. The price of SLU-PP-332 is approximately €425.00 for 100 mg.

Scientific Background: Fatty Acid Oxidation

Current discussions around SLU-PP-332 in research literature focus on experimental mechanisms rather than clinical or therapeutic applications. SLU-PP-332 is a synthetic, small-molecule drug classified as an exercise mimetic and a pan-estrogen related receptor (ERR) agonist, developed to replicate the biological and metabolic effects of aerobic exercise at a cellular level. It acts as an agonist for the estrogen-related receptor (ERR)α, ERRβ, and ERRγ nuclear receptors, and was developed for research purposes. In vivo studies, SLU-PP-332 is administered to animals (mice) via injection to examine its effects on metabolism, energy expenditure, and fat accumulation.

SLU-PP-332 administration mimics exercise-induced benefits on whole-body metabolism in mice, including increased energy expenditure, fatty acid oxidation, and decreased fat mass accumulation, even when food intake remains unchanged. SLU-PP-332 made obese mice gain 10x less fat than untreated mice and lose 12% of their body weight by boosting their metabolism. It effectively reduced obesity and improved insulin sensitivity in models of metabolic syndrome, and preliminary findings indicate it may aid in the treatment of Type 2 diabetes and metabolic syndrome. SLU-PP-332 increases endurance, helping mice run nearly 50% further than before, and increases exercise tolerance and VO₂ max in sedentary mice, all without the mice lifting a paw or increasing physical activity. It enhances mitochondrial function and cellular respiration in skeletal muscle cell lines, and increases oxidative fibers in skeletal muscle, improving exercise endurance. SLU-PP-332 increases the expression of an estrogen receptor-related orphan receptor target gene, and gene expression and protein expression are measured in cell based assays and skeletal muscle cell lines to assess its effects. It is utilized in metabolic and mitochondrial research examining lipid metabolism, and is used in cell based assays and animal models to study its effects on mitochondrial function, energy metabolism, and metabolic diseases. SLU-PP-332 has shown potential for cardioprotection, suggesting it could strengthen heart muscle and maintain oxidative metabolism during heart failure. SLU-PP-332 treatment increased resting energy expenditure in mouse models of obesity/metabolic syndrome. It is designed to stimulate the production of new mitochondria, enhancing cellular energy efficiency and respiration. SLU-PP-332 increases fatty acid oxidation and decreases fat mass accumulation. Pharmacological activation of ERR by SLU-PP-332 may be an effective method to treat metabolic syndrome. SLU-PP-332 is used in vivo and in vitro tests, including cell based assays, to examine its effects on gene expression, protein expression, and metabolic parameters. Food intake and body weight are monitored in animals during treatment, and food consumption remains unchanged despite metabolic improvements. The effects of SLU-PP-332 are observed and examined in animal models, and various tests (such as glucose tolerance tests) are used to assess metabolic outcomes. SLU-PP-332 is not approved for human use, and there are no published human trials, so its safety and long-term effects in humans are unknown. The development of compounds like SLU-PP-332 prompts ethical discussions regarding performance-enhancing agents and their societal implications. Relevant research includes studies by Billon C (Cell Metab, 2022), Narkar VA, and articles in J Biol Chem. SLU-PP-332 is used to study aging, metabolic syndrome, obesity, diabetes, and the effects of physical activity and increasing physical activity on metabolism. It is used to help understand the role of fatty acids, proteins, and gene expression in energy metabolism and mitochondrial function. SLU-PP-332 is used in research to develop new treatments for metabolic diseases and to study the effects of exercise mimetics on animals’ metabolism.