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SLU-PP-332 is a research compound discussed in scientific literature for its unique properties and mechanisms explored in controlled research settings. SLU-PP-332 is classified as a pan ERR agonist, meaning it activates all three estrogen-related receptor subtypes: ERRα, ERRβ, and ERRγ. It acts as a pan-Estrogen Receptor/ERR agonist with EC50 values of 98 nM for ERRα, 230 nM for ERRβ, and 430 nM for ERRγ. SLU-PP-332 increases the expression of mitochondrial biogenesis and oxidative phosphorylation genes. This page provides an educational overview, focusing on its scientific background, classification, and research-only context.
Store in a cool, dry place away from light. The product is stable enough for a few weeks during ordinary shipping and time spent in Customs, but should be stored at -20°C for long-term storage. For longer term storage, freezing at -20°C is recommended to maintain integrity. SLU-PP-332 is for laboratory research use only, not for human or veterinary use. SLU-PP-332 is not approved for human consumption by the FDA and is considered a research chemical.
Proper handling and storage of SLU-PP-332 are essential to preserve its potency and ensure reliable results in research applications. As a powerful exercise mimetic, SLU-PP-332 is widely studied for its ability to enhance fatty acid oxidation, stimulate mitochondrial biogenesis, and improve whole body metabolism—particularly in models involving obese mice and skeletal muscle. Maintaining the stability of this compound is critical for experiments investigating metabolic diseases, energy metabolism, and the physiological effects of increased exercise capacity.
To support accurate and reproducible findings, SLU-PP-332 should always be stored in a cool, dry environment, shielded from light, and, for extended periods, kept at -20°C. Careful handling minimizes the risk of contamination or degradation, which is especially important when studying its impact on skeletal muscle function, body weight regulation, and mitochondrial activity in animal models. Researchers should consult the vial label and batch specific data for accurate technical data, and refer to the Certificate of Analysis for further details. Additionally, proper disposal protocols must be followed to ensure laboratory safety and compliance with research standards.
By adhering to these guidelines, researchers can confidently explore the effects of SLU-PP-332 on fatty acid oxidation, energy metabolism, and mitochondrial biogenesis, advancing our understanding of metabolic diseases and the potential of exercise mimetics in experimental therapeutics.
All products such are shipped in lyophilized or powder form and must be reconstituted to a liquid for research and testing. SLU-PP-332 is a synthetic, small-molecule compound developed for research purposes by researchers at Saint Louis University (SLU), also known as louis university. SLU-PP-332 is commercially available for research purposes. We are unable to provide any dosing instructions. All peptides are for research use only. We’re an expert biotechnology company that provides high quality peptides and products for purchase to advance scientific research in this field. The price of SLU-PP-332 is approximately €425.00 for 100 mg.
Current discussions around SLU-PP-332 in research literature focus on experimental mechanisms rather than clinical or therapeutic applications. SLU-PP-332 is a synthetic ERR agonist and a pan agonist, with the full chemical name naphthalen-2-ylmethylene benzohydrazide. It is a small-molecule drug classified as an exercise mimetic and a pan-estrogen related receptor (ERR) agonist, developed to replicate the biological and metabolic effects of aerobic exercise at a cellular level. It acts as an agonist for the estrogen-related receptor (ERR)α, ERRβ, and ERRγ nuclear receptors, and was developed for research purposes. The product molecular weight is batch specific, and batch specific molecular weights may vary due to hydration levels; researchers should check the vial label or Certificate of Analysis for the exact value. To prepare stock solutions, researchers should refer to batch specific data and use a reconstitution calculator and dilution calculator to quickly calculate the solvent volumes required, target concentration, and concentration required (e.g., mg/mL) for accurate stock solution preparation. Solvent volumes and dilution required are influenced by the product molecular weight and hydration state. Benzohydrazide purity (≥98% by HPLC) is important for research applications. Chemical identifiers and structural features such as c c1, cc c, and c c1 cc are relevant to ERR agonists. The InChi Key for SLU-PP-332 is provided for unambiguous chemical identification. The following data: technical data provided is for general guidance, and batch specific data refer to the Certificate of Analysis for accuracy and transparency.
In vivo studies, SLU-PP-332 is administered to animals (mice) via injection to examine its effects on metabolism, energy expenditure, and fat accumulation. SLU-PP-332 is used in mouse models to study mitochondrial dysfunction, improves insulin sensitivity, increases mitochondrial respiration, and enhances exercise capacity and muscle function. Treatment with SLU-PP-332 leads to increased cellular respiration rates and metabolic efficiency without cytotoxicity. Current research models of SLU-PP-332 typically use subcutaneous injections, with efforts underway to develop an oral tablet for future human trials. In studies on obese mice, SLU-PP-332 resulted in a 12% loss in body weight over a month without reducing food intake. Treatment with SLU-PP-332 increases expression of mitochondrial biogenesis and oxidative phosphorylation genes, leading to enhanced mitochondrial function, oxygen consumption, and ATP production. SLU-PP-332 is used in laboratory research, and proper laboratory research protocols should be followed.
SLU-PP-332 administration mimics exercise-induced benefits on whole-body metabolism in mice, including increased energy expenditure, fatty acid oxidation, and decreased fat mass accumulation, even when food intake remains unchanged. SLU-PP-332 made obese mice gain 10x less fat than untreated mice and lose 12% of their body weight by boosting their metabolism. It effectively reduced obesity and improved insulin sensitivity in models of metabolic syndrome, and preliminary findings indicate it may aid in the treatment of Type 2 diabetes and metabolic syndrome. SLU-PP-332 increases endurance, helping mice run nearly 50% further than before, and increases exercise tolerance and VO₂ max in sedentary mice, all without the mice lifting a paw or increasing physical activity. It enhances mitochondrial function and cellular respiration in skeletal muscle cell lines, and increases oxidative fibers in skeletal muscle, improving exercise endurance. SLU-PP-332 increases the expression of an estrogen receptor-related orphan receptor target gene, and gene expression and protein expression are measured in cell based assays and skeletal muscle cell lines to assess its effects. It is utilized in metabolic and mitochondrial research examining lipid metabolism, and is used in cell based assays and animal models to study its effects on mitochondrial function, energy metabolism, and metabolic diseases. SLU-PP-332 has shown potential for cardioprotection, suggesting it could strengthen heart muscle and maintain oxidative metabolism during heart failure. SLU-PP-332 treatment increased resting energy expenditure in mouse models of obesity/metabolic syndrome. It is designed to stimulate the production of new mitochondria, enhancing cellular energy efficiency and respiration. SLU-PP-332 increases fatty acid oxidation and decreases fat mass accumulation. Pharmacological activation of ERR by SLU-PP-332 may be an effective method to treat metabolic syndrome. SLU-PP-332 is used in vivo and in vitro tests, including cell based assays, to examine its effects on gene expression, protein expression, and metabolic parameters. Food intake and body weight are monitored in animals during treatment, and food consumption remains unchanged despite metabolic improvements. The effects of SLU-PP-332 are observed and examined in animal models, and various tests (such as glucose tolerance tests) are used to assess metabolic outcomes. SLU-PP-332 is not approved for human use, and there are no published human trials, so its safety and long-term effects in humans are unknown. The development of compounds like SLU-PP-332 prompts ethical discussions regarding performance-enhancing agents and their societal implications. Relevant research includes studies by Billon C (Cell Metab, 2022), Narkar VA, and articles in J Biol Chem. SLU-PP-332 is used to study aging, metabolic syndrome, obesity, diabetes, and the effects of physical activity and increasing physical activity on metabolism. It is used to help understand the role of fatty acids, proteins, and gene expression in energy metabolism and mitochondrial function. SLU-PP-332 is used in research to develop new treatments for metabolic diseases and to study the effects of exercise mimetics on animals’ metabolism.
Additional scientific context related to compounds can be found through publicly available research databases such as PubChem.
For further information on purity please visit Certificates of Analysis.
To learn more about our research disclaimers please visit our page Research-only disclaimer.
Research peptides are amino-acid chains used in labs to study how the body works. They are for research use only—not for human or animal consumption.
No prescription is required. By purchasing, you confirm products will be used strictly for research purposes only and in compliance with applicable laws and regulations.
For long-term storage, lyophilized peptides should be kept in the freezer. After reconstitution, store peptides in the refrigerator and use promptly for research.
We do not provide usage or dosing instructions. Products are for research/testing only, and no medical or experimental guidance is offered.
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